Popular Amtrak Routes from West Virginia West Virginia is home to several scenic Amtrak routes that connect it to major cities and attractions: Cardinal Route: Runs from New York City to Chicago, passing through Huntington, Charleston, and White Sulphur Springs. This route offers breathtaking views of the Appalachian Mountains and the New River Gorge. Amtrak Thruway Service: ... https://bookamtraktrain.com/booking-amtrak-in-west-virginia/