Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts with the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have discovered recurrent mutations in genes regulating tumor cell-microenvironment interactions, whi... https://henryv753oyg0.techionblog.com/profile