DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes through a few nucleotidyl transfer techniques involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal structures of DNA ligases sure to nucleotide and nucleic acid substrates have illumin... https://ligaz-bet17036.newbigblog.com/33901442/manual-article-review-is-required-for-this-article