Here, we show that conolidine, a pure analgesic alkaloid used in traditional Chinese medication, targets ACKR3, thus delivering supplemental proof of the correlation amongst ACKR3 and discomfort modulation and opening alternate therapeutic avenues for the procedure of Serious suffering. We demonstrated that, in contrast to classical opioid receptors, ACKR3 https://conolidineahistoryofnatur21864.diowebhost.com/82885596/not-known-facts-about-conolidine