Pretreatment with probenecid minimizes both equally the natriuresis and hyperreninemia made by Bumex. This antagonistic outcome of probenecid on Bumex natriuresis will not be as a consequence of a direct motion on sodium excretion but is probably secondary to its inhibitory impact on renal tubular secretion of bumetanide. Thus, probenecid http://www.arcadetrainer.com/index.php?params=profile/view/2831408/